Basic Information

Symbol
STAT1
RNA class
mRNA
Alias
Signal Transducer And Activator Of Transcription 1 Transcription Factor ISGF-3 Components P91/P84 STAT91 ISGF-3 Signal Transducer And Activator Of Transcription 1-Alpha/Beta Signal Transducer And Activator Of Transcription 1, 91kDa Signal Transducer And Activator Of Transcription 1, 91kD CANDF7 IMD31A IMD31B IMD31C
Location (GRCh38)
2:190908460-191020960
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_007315.4
Sequence length
4116.0 nt
GC content
0.4327

Transcripts

ID Sequence Length GC content
NM_001384890.1 NCBI
GUUUCGCUUUCCUGCGCAGAGUCUGCGGAGGGGCUCGGCUGCACCGGGG… 4026 nt 0.4329
NM_001384891.1 NCBI
GUUUCGCUUUCCUGCGCAGAGUCUGCGGAGGGGCUCGGCUGCACCGGGG… 4152 nt 0.4314
NM_007315.4 NCBI
GUUUCGCUUUCCUGCGCAGAGUCUGCGGAGGGGCUCGGCUGCACCGGGG… 4116 nt 0.4327
NM_139266.3 NCBI
GUUUCGCUUUCCUGCGCAGAGUCUGCGGAGGGGCUCGGCUGCACCGGGG… 2718 nt 0.4676
Showing 11 to 14 of 14 entries
Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020] CIViC Summary for STAT1 Gene

Forensic Context

A study in mice demonstrated that the mRNA and protein expression levels of the STAT1 were significantly decreased in burn tissue compared to normal skin [Guo et al. DOI:10.1155/2022/5220403].