Basic Information

Symbol
STAT5A
RNA class
mRNA
Alias
Signal Transducer And Activator Of Transcription 5A STAT5 MGF Epididymis Secretory Sperm Binding Protein
Location (GRCh38)
17:42287547-42311943
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001288718.2
Sequence length
3770.0 nt
GC content
0.5674

Transcripts

ID Sequence Length GC content
NM_001288718.2 NCBI
AGUAACAGCCGCCGCUGCCGCCGCCGCCAGGAACCCCGGCCGGGAGCGA… 3770 nt 0.5674
NM_001288719.2 NCBI
AGUAACAGCCGCCGCUGCCGCCGCCGCCAGGAACCCCGGCCGGGAGCGA… 3680 nt 0.5679
NM_001288720.2 NCBI
AGUAACAGCCGCCGCUGCCGCCGCCGCCAGGAACCCCGGCCGGGAGCGA… 3677 nt 0.5668
NM_001411103.1 NCBI
AGAGGAGAGGGAAGCUGGGCAAAGGGGAUGGAAGGCGUCCAGCCCGACC… 3950 nt 0.5686
NM_003152.4 NCBI
AGACAGGAUAUUCACUGCUGUGGCAAGGCCUGUAGAGAGUUUCGAAGUU… 4301 nt 0.5782
Summary

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

Forensic Context

A study in human sepsis patients identified the STAT5A as a core protein located at the center of a protein-protein interaction network derived from differentially expressed genes in peripheral blood [Liu et al. DOI:10.0000000000002072]. A study in rats demonstrated that the STAT5A mRNA expression in iliopsoas muscle was significantly decreased under moderate hypothermia conditions [Umehara et al. DOI:10.1016/j.legalmed.2022.102150].