Basic Information

Symbol
STEAP1
RNA class
mRNA
Alias
STEAP Family Member 1 PRSS24 STEAP Six Transmembrane Epithelial Antigen Of The Prostate 1 Six-Transmembrane Epithelial Antigen Of Prostate 1 STEAP1 Metalloreductase STEAP1 Protein Six Transmembrane Epithelial Antigen Of The Prostate Metalloreductase STEAP1
Location (GRCh38)
7:90154436-90164829
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_012449.3
Sequence length
1219.0 nt
GC content
0.3995

Transcripts

ID Sequence Length GC content
NM_012449.3 NCBI
AGGCGCCGCGUGGGGCCCGCACCUCUGGGCAGCAGCGGCAGCCGAGACU… 1219 nt 0.3995
Summary

This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human HT-29 colorectal adenocarcinoma cells demonstrated that exposure to arsenic trioxide (As2O3) significantly suppressed the STEAP1 by -6.1-fold according to microarray analysis, with a decreasing tendency observed via qRT-PCR [Kazuta et al. DOI:10.1016/J.Legalmed.2026.102774].