Basic Information

Symbol
STEAP2
RNA class
mRNA
Alias
STEAP2 Metalloreductase STAMP1 PCANAP1 STMP Six Transmembrane Epithelial Antigen Of The Prostate 2 Protein Up-Regulated In Metastatic Prostate Cancer Six-Transmembrane Epithelial Antigen Of Prostate 2 STEAP Family Member 2, Metalloreductase SixTransMembrane Protein Of Prostate 1 Prostate Cancer-Associated Protein 1 Metalloreductase STEAP2 IPCA-1 PUMPCn Protein Upregulated In Metastatic Prostate Cancer Prostate Cancer Associated Protein 1 EC 1.16.1.- EC 1.16.1 IPCA1
Location (GRCh38)
7:90167590-90238137
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001244944.2
Sequence length
6984.0 nt
GC content
0.3655

Transcripts

ID Sequence Length GC content
NM_001040665.2 NCBI
AGUCAGCGUUCCUCGGGCCCUCGGCGCCACGAGCUGUCCGGGCACGCAG… 6821 nt 0.3592
NM_001040666.2 NCBI
UUCUGCUAUAGAGAUGGAACAGUAUAUGGAAAGCUCCCAAGAAAGUGAA… 2313 nt 0.3865
NM_001244944.2 NCBI
AGUCAGCGUUCCUCGGGCCCUCGGCGCCACGAGCUGUCCGGGCACGCAG… 6984 nt 0.3655
NM_001244945.2 NCBI
AGUCAGCGUUCCUCGGGCCCUCGGCGCCACGAGCUGUCCGGGCACGCAG… 2465 nt 0.4308
NM_001244946.2 NCBI
AGUCAGCGUUCCUCGGGCCCUCGGCGCCACGAGCUGUCCGGGCACGCAG… 2267 nt 0.4195
NM_152999.4 NCBI
AGUCAGCGUUCCUCGGGCCCUCGGCGCCACGAGCUGUCCGGGCACGCAG… 6871 nt 0.3647
Summary

This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human HT-29 colorectal adenocarcinoma cells demonstrated that exposure to arsenic trioxide (As2O3) significantly suppressed the STEAP2 gene by -4.55-fold according to microarray analysis, with a decreasing tendency confirmed by qRT-PCR [Kazuta et al. DOI:10.1016/J.Legalmed.2026.102774].