Basic Information

Symbol
STEAP3
RNA class
mRNA
Alias
STEAP3 Metalloreductase TSAP6 Dudlin-2 STMP3 Six-Transmembrane Epithelial Antigen Of Prostate 3 Tumor Suppressor-Activated Pathway Protein 6 STEAP Family Member 3, Metalloreductase Metalloreductase STEAP3 Ferrireductase Dudulin-2 PHyde Tumor Suppressor PHyde EC 1.16.1.- AHMIO2 HTSAP6 HpHyde
Location (GRCh38)
2:119222447-119265652
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_182915.3
Sequence length
4259.0 nt
GC content
0.5684

Transcripts

ID Sequence Length GC content
NM_001008410.2 NCBI
GCCUUCGCCGCGGACCUUCAGCUGCCGCGGUCGCUCCGAGCGGCGGGCC… 3844 nt 0.5663
NM_018234.3 NCBI
GCCUUCGCCGCGGACCUUCAGCUGCCGCGGUCGCUCCGAGCGGCGGGCC… 3912 nt 0.5665
NM_138637.3 NCBI
GCCUUCGCCGCGGACCUUCAGCUGCCGCGGUCGCUCCGAGCGGCGGGCC… 4076 nt 0.5650
NM_182915.3 NCBI
GCCUUCGCCGCGGACCUUCAGCUGCCGCGGUCGCUCCGAGCGGCGGGCC… 4259 nt 0.5684
Summary

This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Forensic Context

A study in rats and L6 myoblasts demonstrated that skeletal muscle contusion induces iron overload and ferroptosis, characterized by increased Fe2+ and MDA alongside decreased GSH and GPX4, with these effects reversed by ferroptosis inhibitors [Yang et al. DOI:10.3390/ijms252011317]. In human HT-29 colorectal adenocarcinoma cells, arsenic trioxide exposure significantly suppressed the STEAP3 gene, though it was not detectable by qRT-PCR under the experimental conditions, while other heavy metals elicited diverse and metal-specific regulatory patterns for related STEAP and MT genes [Kazuta et al. DOI:10.1016/J.Legalmed.2026.102774].