Basic Information

Symbol
STING1
RNA class
mRNA
Alias
Stimulator Of Interferon Response CGAMP Interactor 1 STING ERIS MITA Transmembrane Protein 173 TMEM173 NET23 MPYS Endoplasmic Reticulum Interferon Stimulator Stimulator Of Interferon Genes Protein Endoplasmic Reticulum IFN Stimulator FLJ38577 HSTING HMITA N-Terminal Methionine-Proline-Tyrosine-Serine Plasma Membrane Tetraspanner Stimulator Of Interferon Response CGAMP Interactor-DeltaC Stimulator Of Interferon Response CGAMP Interactor-DeltaN Mitochondrial Mediator Of IRF3 Activation Stimulator Of Interferon Protein Stimulator Of Interferon Genes Mediator Of IRF3 Activation STING-Beta Sting 1 SAVI
Location (GRCh38)
5:139475528-139482935
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_198282.4
Sequence length
2170.0 nt
GC content
0.5696

Transcripts

ID Sequence Length GC content
NM_001301738.2 NCBI
GUUCAUUUUUCACUCCUCCCUCCUAGGUCACACUUUUCAGAAAAAGAAU… 1983 nt 0.5693
NM_001367258.1 NCBI
GUUCAUUUUUCACUCCUCCCUCCUAGGUCACACUUUUCAGAAAAAGAAU… 1943 nt 0.5610
NM_198282.4 NCBI
GUUCAUUUUUCACUCCUCCCUCCUAGGUCACACUUUUCAGAAAAAGAAU… 2170 nt 0.5696
Summary

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Forensic Context

A study in humans demonstrated that the STING1 showed a higher trend in post-myocardial infarction heart failure patients compared to non-heart failure patients in PCR validation, as part of a broader investigation into immune cell subtypes for risk prediction [Sun et al. DOI:10.3389/fimmu.2023.1163350].