Basic Information

Symbol
STK17B
RNA class
mRNA
Alias
Serine/Threonine Kinase 17b DRAK2 DAP Kinase-Related Apoptosis-Inducing Protein Kinase 2 Death-Associated Protein Kinase-Related 2 Serine/Threonine-Protein Kinase 17B EC 2.7.11.1 Serine/Threonine Kinase 17b (Apoptosis-Inducing) EC 2.7.11
Location (GRCh38)
2:196133583-196176503
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004226.4
Sequence length
5273.0 nt
GC content
0.3672

Transcripts

ID Sequence Length GC content
NM_004226.4 NCBI
AAACCGCGACUGCAAGCUUCGGUAGUCCUCUCCGCUGCUGUCGCCAGGA… 5273 nt 0.3672
Summary

Enables ATP binding activity and protein serine/threonine kinase activity. Involved in intracellular signal transduction; positive regulation of fibroblast apoptotic process; and protein phosphorylation. Located in Flemming body and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mouse cardiac mesenchymal stem cells demonstrated that overexpression of the STK17B activated cell cycle pathways and promoted proliferation, with RNA-seq identifying STK17B (DRAK2) as an upregulated hub gene in this transcriptional reprogramming [Zhang et al. DOI:10.3390/biom15050662].