Basic Information

Symbol
STK38
RNA class
mRNA
Alias
Serine/Threonine Kinase 38 NDR1 NDR Serine/Threonine-Protein Kinase 38 Nuclear Dbf2-Related Kinase 1 NDR1 Protein Kinase EC 2.7.11.1 Ndr Ser/Thr Kinase-Like Protein Nuclear Dbf2-Related 1 EC 2.7.11
Location (GRCh38)
6:36493880-36547516
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_007271.4
Sequence length
3585.0 nt
GC content
0.4558

Transcripts

ID Sequence Length GC content
NM_001305102.2 NCBI
AUGCGUAGUCUCGGCCCCGGGCUGCCGCGCCAGCCCGUCUCCGCGGCGG… 3582 nt 0.4556
NM_007271.4 NCBI
AUGCGUAGUCUCGGCCCCGGGCUGCCGCGCCAGCCCGUCUCCGCGGCGG… 3585 nt 0.4558
Summary

This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Forensic Context

A study in mice selectively bred for high (MAHDR) or low (MALDR) methamphetamine intake identified the STK38 as a network hub gene overexpressed in the MALDR line within the ventral midbrain, where it was a hub node in the green coexpression module with connectivity differing by at least 0.5 between the lines [Hitzemann et al. DOI:10.3390/brainsci9070155].