Basic Information

Symbol
STMN1
RNA class
mRNA
Alias
Stathmin 1 OP18 Oncoprotein 18 C1orf215 LAP18 PR22 PP19 PP17 SMN Lag Leukemia-Associated Phosphoprotein P18 Stathmin 1/Oncoprotein 18 Phosphoprotein P19 Metablastin FLJ32206 Stathmin Prosolin Chromosome 1 Open Reading Frame 215 Testicular Tissue Protein Li 189 Transmembrane Protein C1orf215 Phosphoprotein 19 Protein Pr22 Op18 Pp19 Pp17
Location (GRCh38)
1:25884181-25907237
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Sudden death from CNS diseases
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005563.4
Sequence length
1443.0 nt
GC content
0.4310

Transcripts

ID Sequence Length GC content
NM_001145454.3 NCBI
AGAGUGUGGUCAGGCGGCUCGGACUGAGCAGGACUUUCCUUAUCCCAGU… 2162 nt 0.4977
NM_005563.4 NCBI
AGAGUGUGGUCAGGCGGCUCGGACUGAGCAGGACUUUCCUUAUCCCAGU… 1443 nt 0.4310
NM_203399.2 NCBI
AGAAGGGGCACUGCUCUGUCCGAGUGCUGCCCUUGGGGCGAGGCGGGCA… 1505 nt 0.4385
NM_203401.2 NCBI
AUUGUCUGAAGGGACGGGGCGGUGCCCCAGGGACCAGCGGCUUUAGGAC… 1606 nt 0.4620
Summary

This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] CIViC Summary for STMN1 Gene

Forensic Context

A study in mice demonstrated that the STMN1 is a hub gene highly expressed 3-days after spinal cord injury, where it is closely related to ferroptosis and immune cell infiltration, and its diagnostic efficacy was confirmed with an AUC of 0.999 [Bao et al. DOI:10.1186/s13018-023-04195-5]. In human skin, the STMN1 was identified as a marker for proliferating basal keratinocytes (Bas-prolif) during wound healing [Liu et al. DOI:10.1016/j.stem.2024.11.013].