Basic Information

Symbol
STRA6
RNA class
mRNA
Alias
Signaling Receptor And Transporter Of Retinol STRA6 SLC69A1 Stimulated By Retinoic Acid Gene 6 Protein Homolog Retinol-Binding Protein Receptor STRA6 Retinol Binding Protein 4 Receptor Receptor For Retinol Uptake STRA6 RBP Receptor FLJ12541 Stimulated By Retinoic Acid Gene 6 Homolog (Mouse) Stimulated By Retinoic Acid Gene 6 Homolog Stimulated By Retinoic Acid 6 Homolog Stimulated By Retinoic Acid 6 MCOPCB8 PP14296 MCOPS9
Location (GRCh38)
15:74179466-74212267
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_022369.4
Sequence length
2708.0 nt
GC content
0.6123

Transcripts

ID Sequence Length GC content
NM_001142617.2 NCBI
AGGGCCAACUGCCGAGACCACACAACCAGCCACCCCUCUAGGAUCCCAG… 2823 nt 0.6100
NM_001142618.2 NCBI
ACUGCAGAUGUGGCGGGCAGGGGCUUGGGAGCUCUGGGGCAGGCGCUGA… 2688 nt 0.6131
NM_001142619.2 NCBI
AGGGCCAACUGCCGAGACCACACAACCAGCCACCCCUCUAGGAUCCCAG… 2796 nt 0.6102
NM_001142620.2 NCBI
AGGGCCAACUGCCGAGACCACACAACCAGCCACCCCUCUAGGAUCCCAG… 1900 nt 0.5742
NM_001199040.2 NCBI
GUGCUCAGGUGAGGGGGGAUGCAGCCGACUGUCCAGCAGCGUUGGAGGU… 2980 nt 0.6074
NM_001199041.2 NCBI
AUGUUAUGAUGAUGCUGUUGGUGAGGGGGGCAUGAGAAUUGCAGGAAGG… 2991 nt 0.6068
NM_001199042.2 NCBI
AGGCAGUGCGGAGCUGGCCGUGGGCUGCCUACCCUUUCAUCUCUGCAAC… 3003 nt 0.6117
NM_022369.4 NCBI
AGGCAGUGCGGAGCUGGCCGUGGGCUGCCUACCCUUUCAUCUCUGCAAC… 2708 nt 0.6123
Summary

The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Forensic Context

A study in mice identified STRA6 as a transcript with highly specific enhanced expression in the nucleus accumbens shell, where it was used as a seed for a topographic transcriptomic analysis to identify novel targets for cocaine use disorder [Crofton et al. DOI:10.1016/J.Neuropharm.2020.108398].