Basic Information

Symbol
STRIT1
RNA class
mRNA
Alias
Small Transmembrane Regulator Of Ion Transport 1 DWORF Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase Regulator DWORF SERCA Regulator DWORF Dwarf Open Reading Frame
Location (GRCh38)
3:155290227-155293683
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001352129.2
Sequence length
783.0 nt
GC content
0.3525

Transcripts

ID Sequence Length GC content
NM_001352129.2 NCBI
CAAAAGAAAGAGGUAAGCGUGGCCUGACCUAGCCACCCACCAACAGGAA… 783 nt 0.3525
Summary

Predicted to enable enzyme activator activity. Predicted to be involved in regulation of calcium ion transport and regulation of striated muscle contraction. Predicted to act upstream of or within positive regulation of ATPase-coupled calcium transmembrane transporter activity and positive regulation of calcium ion import. Predicted to be located in sarcoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]

Forensic Context

A review of long noncoding RNAs in cardiovascular diseases noted that in Drosophila, the micropeptide DWORF, derived from a long noncoding RNA, enhances cardiac contractility by decreasing the time of individual contraction-relaxation cycles through interference with SERCA inhibitors like phospholamban [Chih-Fan Yeh et al. DOI:10.1186/s12929-020-00647-w].