Basic Information

Symbol
STX12
RNA class
mRNA
Alias
Syntaxin 12 STX13 STX14 Syntaxin-12
Location (GRCh38)
Forensic tag(s)
Drug abuse diagnoses

MANE select

Transcript ID
NM_177424.3
Sequence length
3034.0 nt
GC content
0.4031

Transcripts

ID Sequence Length GC content
CCCAGUUUCUCCGUCAGCCUGCGGGUCCCGGCUGGCGGCUGCUUCCGGU… 3034 nt 0.4031
Summary

Predicted to enable SNAP receptor activity and SNARE binding activity. Involved in autophagosome assembly; cholesterol efflux; and protein stabilization. Located in several cellular components, including BLOC-1 complex; phagocytic vesicle; and phagophore assembly site. Part of SNARE complex. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in rats demonstrated that cortical gene expression differences exist between ethanol-preferring and nonpreferring strains, with quantitative RT-PCR confirming significant mRNA up-regulation of VAMP2, STX1a, STX1b, MUNC-18, and cacna2d1, and down-regulation of mGluR3 in AA versus ANA lines [Worst et al. DOI:10.1002/Jnr.20496].