Basic Information

Symbol
STX1A
RNA class
mRNA
Alias
Syntaxin 1A HPC-1 P35-1 STX1 Neuron-Specific Antigen HPC-1 Syntaxin 1A (Brain) Syntaxin-1A SYN1A
Location (GRCh38)
7:73699205-73719691
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004603.4
Sequence length
2102.0 nt
GC content
0.6018

Transcripts

ID Sequence Length GC content
NM_001165903.2 NCBI
ACACGGCUGCAGCCGGCGCCGCUGCCACUCCCGGGAGCAUGAAGGACCG… 2056 nt 0.6041
NM_004603.4 NCBI
ACACGGCUGCAGCCGGCGCCGCUGCCACUCCCGGGAGCAUGAAGGACCG… 2102 nt 0.6018
Summary

This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Forensic Context

A study in mice demonstrated that the STX1A was identified as a differentially wired gene in the prefrontal cortex of animals selectively bred for high versus low methamphetamine consumption, indicating its involvement in the transcriptomic basis of addiction risk [Hitzemann et al. DOI:10.3390/brainsci9070155].