Basic Information

Symbol
STX2
RNA class
mRNA
Alias
Syntaxin 2 Epimorphin STX2A STX2B STX2C EPIM EPM Syntaxin-2
Location (GRCh38)
12:130789600-130839265
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_194356.4
Sequence length
3441.0 nt
GC content
0.4319

Transcripts

ID Sequence Length GC content
NM_001351049.2 NCBI
GCGGUUGCCGUGGCAGCGCCGGCUCCAGGGAGGGCUGCUGGCGCCGGGC… 3254 nt 0.4339
NM_001351050.2 NCBI
GCGGUUGCCGUGGCAGCGCCGGCUCCAGGGAGGGCUGCUGGCGCCGGGC… 1072 nt 0.4767
NM_001351051.2 NCBI
GCGGUUGCCGUGGCAGCGCCGGCUCCAGGGAGGGCUGCUGGCGCCGGGC… 3471 nt 0.4336
NM_001351052.2 NCBI
GCGGUUGCCGUGGCAGCGCCGGCUCCAGGGAGGGCUGCUGGCGCCGGGC… 3449 nt 0.4366
NM_001413773.1 NCBI
GCGGUUGCCGUGGCAGCGCCGGCUCCAGGGAGGGCUGCUGGCGCCGGGC… 3310 nt 0.4311
NM_001413775.1 NCBI
GCGGUUGCCGUGGCAGCGCCGGCUCCAGGGAGGGCUGCUGGCGCCGGGC… 3380 nt 0.4346
NM_001980.5 NCBI
GCGGUUGCCGUGGCAGCGCCGGCUCCAGGGAGGGCUGCUGGCGCCGGGC… 3315 nt 0.4311
NM_194356.4 NCBI
GCGGUUGCCGUGGCAGCGCCGGCUCCAGGGAGGGCUGCUGGCGCCGGGC… 3441 nt 0.4319
Summary

The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice selectively bred for high or low methamphetamine consumption identified the STX2 as a differentially wired gene in the prefrontal cortex, indicating its involvement in the transcriptomic networks associated with innate risk for addiction [Hitzemann et al. DOI:10.3390/brainsci9070155]. In a separate study on rats with contusive spinal cord injury, the STX2 was found to be downregulated in the injury epicenter at 35 days post-injury, indicating its involvement in synaptic vesicle protein changes following neural trauma [Aimone et al. DOI:10.1016/j.expneurol.2004.05.042].