Basic Information
MANE select
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| GGAUUUGGAGCGCGAGGCGCCGGUGGGGGCGGAGGGGGCUGCGCGGCGG… | 6040 nt | 0.4488 | |
| GGAUUUGGAGCGCGAGGCGCCGGUGGGGGCGGAGGGGGCUGCGCGGCGG… | 6154 nt | 0.4478 |
Summary
The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Forensic Context
A study in mice demonstrated that the STX3 was identified as a differentially wired gene in the prefrontal cortex of animals selectively bred for high versus low methamphetamine consumption, indicating its involvement in synaptic alterations associated with innate addiction risk [Hitzemann et al. DOI:10.3390/brainsci9070155]. In human traumatic brain injury (TBI) patients, microarray analysis of pericontusional tissue showed the STX3 was up-regulated by 27% in one patient, categorizing it among adhesion factors and contact recognition molecules altered by brain trauma [Michael et al. DOI:10.1016/j.jocn.2004.11.003].