Basic Information

Symbol
STX6
RNA class
mRNA
Alias
Syntaxin 6 Syntaxin-6
Location (GRCh38)
1:180972712-181023121
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005819.6
Sequence length
4810.0 nt
GC content
0.4376

Transcripts

ID Sequence Length GC content
NM_001286210.2 NCBI
GAUUCGGCCAGUGGUGCUGAGCGAGUGCUGGACCAGCGGCCGUCCUGUG… 4545 nt 0.4363
NM_005819.6 NCBI
GAUUCGGCCAGUGGUGCUGAGCGAGUGCUGGACCAGCGGCCGUCCUGUG… 4810 nt 0.4376
Summary

Enables syntaxin binding activity. Involved in regulation of protein localization; retrograde transport, endosome to Golgi; and vesicle fusion. Acts upstream of or within endocytic recycling. Located in several cellular components, including early endosome; perinuclear region of cytoplasm; and trans-Golgi network. Part of SNARE complex. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that the STX6 was identified as a differentially wired gene in the prefrontal cortex of animals selectively bred for high versus low methamphetamine consumption, indicating its involvement in the transcriptomic networks associated with innate risk for addiction [Hitzemann et al. DOI:10.3390/brainsci9070155].