Basic Information

Symbol
STXBP1
RNA class
mRNA
Alias
Syntaxin Binding Protein 1 MUNC18-1 Syntaxin-Binding Protein 1 RbSec1 UNC18 NSec1 Protein Unc-18 Homolog 1 Protein Unc-18 Homolog A Unc-18A Unc18-1 HUNC18 N-Sec1 P67 Neuronal SEC1 UNC18A DEE4
Location (GRCh38)
9:127579370-127696027
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001032221.6
Sequence length
3754.0 nt
GC content
0.5197

Transcripts

ID Sequence Length GC content
NM_001374315.2 NCBI
AGUCGGUCCCUAGCGCGGCUGCGGGGCGGAGAGCUGCGGCUGGCCCAGC… 3772 nt 0.5148
NM_003165.6 NCBI
AGUCGGUCCCUAGCGCGGCUGCGGGGCGGAGAGCUGCGGCUGGCCCAGC… 3880 nt 0.5180
Showing 11 to 12 of 12 entries
Summary

This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]

Forensic Context

A study in mice demonstrated that a running exercise intervention significantly shortened methamphetamine-induced conditioned place preference from 6 to 3 days and identified 12 differentially expressed genes in the hippocampus, including the STXBP1 which was downregulated in the exercised, methamphetamine-addicted group [Li et al. DOI:10.21037/atm-22-450]. A study in mice demonstrated that a running exercise intervention significantly shortened methamphetamine-induced conditioned place preference and identified 12 differentially expressed genes in the hippocampus, including the STXBP1 which was down-regulated in the METH-addicted group receiving exercise [Li et al. DOI:10.21037/Atm-22-450]. In rats, research on ethanol-naive, genetically selected lines found the STXBP1 mRNA was up-regulated in the frontal cortex of alcohol-preferring AA rats compared to alcohol-avoiding ANA rats, a finding confirmed by quantitative RT-PCR [Worst et al. DOI:10.1002/Jnr.20496].