Basic Information

Symbol
STXBP5
RNA class
mRNA
Alias
Syntaxin Binding Protein 5 Tomosyn-1 LLGL3 Tomosyn Lethal(2) Giant Larvae Protein Homolog 3 Syntaxin-Binding Protein 5 Putative Protein Product Of Nbla04300 Nbla04300 LGL3
Location (GRCh38)
6:147203710-147391010
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001127715.4
Sequence length
9290.0 nt
GC content
0.3578

Transcripts

ID Sequence Length GC content
NM_001127715.4 NCBI
ACACUCCCACUCCUCCGUUUCCGCGGUCGAAGCUGCCUUCGGCCCCGGG… 9290 nt 0.3578
NM_001394409.1 NCBI
ACACUCCCACUCCUCCGUUUCCGCGGUCGAAGCUGCCUUCGGCCCCGGG… 9242 nt 0.3577
NM_139244.6 NCBI
ACACUCCCACUCCUCCGUUUCCGCGGUCGAAGCUGCCUUCGGCCCCGGG… 9182 nt 0.3582
Summary

Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans demonstrated that the STXBP5 exhibited a Gini impurity score of 0, being present in all pure vaginal fluid samples but absent in mixtures containing vaginal fluid and in mixtures without vaginal fluid, indicating its high discriminatory power for body fluid classification [Shehata et al. DOI:10.1016/j.fsigen.2025.103343].