Basic Information

Symbol
SUCLA2
RNA class
mRNA
Alias
Succinate-CoA Ligase ADP-Forming Subunit Beta Succinate--CoA Ligase [ADP-Forming] Subunit Beta, Mitochondrial ATP-Specific Succinyl-CoA Synthetase Subunit Beta Long Intergenic Non-Protein Coding RNA 444 Succinyl-CoA Synthetase Beta-A Chain EC 6.2.1.5 LINC00444 SCS-BetaA A-SCS Succinyl-CoA Ligase [ADP-Forming] Subunit Beta, Mitochondrial Mitochondrial Succinyl-CoA Ligase [ADP-Forming] Subunit Beta ATP-Specific Succinyl-CoA Synthetase, Beta Subunit Succinate-CoA Ligase, ADP-Forming, Beta Subunit Succinate-CoA Ligase ADP-Forming Beta Subunit Succinate--CoA Ligase (ADP-Forming) Renal Carcinoma Antigen NY-REN-39 Succinate-CoA Ligase Beta Subunit EC 6.2.1 A-BETA MTDPS5
Location (GRCh38)
13:47745736-48037968
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003850.3
Sequence length
2111.0 nt
GC content
0.3837

Transcripts

ID Sequence Length GC content
NM_003850.3 NCBI
AGAAAUGGCGGCCUCCAUGUUCUACGGCAGGCUAGUGGCCGUGGCCACC… 2111 nt 0.3837
Summary

Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]

Forensic Context

No relevant information is available at the moment.