Basic Information

Symbol
SUMO1
RNA class
mRNA
Alias
Small Ubiquitin Like Modifier 1 SMT3H3 SMT3C GMP1 SUMO-1 OFC10 PIC1 UBL1 Ubiquitin-Homology Domain Protein PIC1 Small Ubiquitin-Related Modifier 1 Ubiquitin-Like Protein SMT3C Ubiquitin-Like Protein UBL1 SMT3 Homolog 3 Sentrin SMT3 Suppressor Of Mif Two 3 Homolog 1 (S. Cerevisiae) SMT3 Suppressor Of Mif Two 3 Homolog 1 (Yeast) SMT3 Suppressor Of Mif Two 3 Homolog 1 Ubiquitin-Like 1 (Sentrin) GAP Modifying Protein 1 GAP-Modifying Protein 1 SENP2 Smt3C DAP1 SMT3
Location (GRCh38)
2:202206182-202238599
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003352.8
Sequence length
1523.0 nt
GC content
0.3710

Transcripts

ID Sequence Length GC content
NM_001005781.2 NCBI
GGAAGUGACGCGAGGCGUAGCGGAAGUUACUGCAGCCGCGGUGUUGUGC… 1085 nt 0.3760
NM_001005782.2 NCBI
GGAAGUGACGCGAGGCGUAGCGGAAGUUACUGCAGCCGCGGUGUUGUGC… 1459 nt 0.3687
NM_001371392.1 NCBI
GGAAGUGACGCGAGGCGUAGCGGAAGUUACUGCAGCCGCGGUGUUGUGC… 1531 nt 0.3703
NM_001371393.1 NCBI
GGAAGUGACGCGAGGCGUAGCGGAAGUUACUGCAGCCGCGGUGUUGUGC… 1462 nt 0.3700
NM_001371394.1 NCBI
GGAAGUGACGCGAGGCGUAGCGGAAGUUACUGCAGCCGCGGUGUUGUGC… 1669 nt 0.3853
NM_003352.8 NCBI
GGAAGUGACGCGAGGCGUAGCGGAAGUUACUGCAGCCGCGGUGUUGUGC… 1523 nt 0.3710
Summary

This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

Forensic Context

A review of multi-omics studies for human biological age estimation identified the SUMO1 as an aging-associated transcriptome feature, where its expression was correlated with age in the Framingham Offspring cohort [Solovev et al. DOI:10.1016/j.mad.2019.111192].