Basic Information

Symbol
SUV39H2
RNA class
mRNA
Alias
SUV39H2 Histone Lysine Methyltransferase KMT1B Suppressor Of Variegation 3-9 Homolog 2 Histone-Lysine N-Methyltransferase SUV39H2 Histone Methyltransferase SUV39H2 Histone H3-K9 Methyltransferase 2 Lysine N-Methyltransferase 1B Su(Var)3-9 Homolog 2 H3-K9-HMTase 2 FLJ23414 Suppressor Of Variegation 3-9 Homolog 2 (Drosophila) EC 2.1.1.355 EC 2.1.1.43
Location (GRCh38)
10:14878820-14904315
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001193424.2
Sequence length
3059.0 nt
GC content
0.3844

Transcripts

ID Sequence Length GC content
NM_001193424.2 NCBI
AGUUUGAAUGAAAGCUCUACAAGAUGGCGGCGGUCGGGGCCGAGGCGCG… 3059 nt 0.3844
NM_001193425.2 NCBI
AGUUUGAAUGAAAGCUCUACAAGAUGGCGGCGGUCGGGGCCGAGGCGCG… 3100 nt 0.3890
NM_001193426.2 NCBI
AGUUUGAAUGAAAGCUCUACAAGAUGGCGGCGGUCGGGGCCGAGGCGCG… 2519 nt 0.3831
NM_001193427.2 NCBI
AGUUUGAAUGAAAGCUCUACAAGAUGGCGGCGGUCGGGGCCGAGGCGCG… 2560 nt 0.3887
NM_024670.4 NCBI
AGUUUGAAUGAAAGCUCUACAAGAUGGCGGCGGUCGGGGCCGAGGCGCG… 3121 nt 0.4120
Summary

Enables cation binding activity; histone H3K9 methyltransferase activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in epigenetic programming in the zygotic pronuclei. Acts upstream of or within cellular response to hypoxia and negative regulation of transcription by RNA polymerase II. Located in chromatin. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that the SUV39H2 transcript was significantly upregulated in the hippocampus following prenatal ethanol exposure (beta=3.64, p=1.34e-03) and the combined treatment of prenatal ethanol with postnatal maternal separation stress (beta=3.74, p=9.76e-04) [Alberry et al. DOI:10.1186/S11689-020-09316-3].