Basic Information

Symbol
SV2B
RNA class
mRNA
Alias
Synaptic Vesicle Glycoprotein 2B KIAA0735 HsT19680 SLC22B2 Solute Carrier Family 22 Member B2 Synaptic Vesicle Protein 2B Homolog
Location (GRCh38)
15:91099869-91302565
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001323032.3
Sequence length
12563.0 nt
GC content
0.4413

Transcripts

ID Sequence Length GC content
NM_001167580.3 NCBI
GCCCGGAUCGCCCAGCUCCGCGUUAGCCGGAGCUGCACGCGGGGCUGCC… 11721 nt 0.4367
NM_001323031.2 NCBI
AGUGGAGUUAGUGGGUGGUGGUUUGGAAGGAGGGAGACAGAGGUGGAGG… 12559 nt 0.4399
NM_001323032.3 NCBI
GCCCGGAUCGCCCAGCUCCGCGUUAGCCGGAGCUGCACGCGGGGCUGCC… 12563 nt 0.4413
NM_001323033.3 NCBI
GCCCGGAUCGCCCAGCUCCGCGUUAGCCGGAGCUGCACGCGGGGCUGCC… 12230 nt 0.4383
NM_001323034.3 NCBI
GCCCGGAUCGCCCAGCUCCGCGUUAGCCGGAGCUGCACGCGGGGCUGCC… 12362 nt 0.4404
NM_001323036.3 NCBI
AGCAAAUGCGUUUAGCCAGGGAGGAGCAAGGCACCGCUGUGUCUUCGGC… 11762 nt 0.4346
NM_001323037.3 NCBI
AGCAAAUGCGUUUAGCCAGGGAGGAGCAAGGCACCGCUGUGUCUUCGGC… 12692 nt 0.4402
NM_001323038.3 NCBI
AGCAAAUGCGUUUAGCCAGGGAGGAGCAAGGCACCGCUGUGUCUUCGGC… 12604 nt 0.4393
NM_001323039.3 NCBI
AGUAUGUGACUAGACCCCAGUAGACACAGGCUGACACCCAGAGAGGAGC… 12981 nt 0.4383
NM_001323040.3 NCBI
AGUAUGUGACUAGACCCCAGUAGACACAGGCUGACACCCAGAGAGGAGC… 12227 nt 0.4346
Showing 1 to 10 of 11 entries
Summary

This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons, and that this protein may be important for the integrity of the glomerular filtration barrier. This gene shows reduced expression in areas of synaptic loss in the hippocampus of human temporal lobe epilepsy patients. [provided by RefSeq, Sep 2016]

Forensic Context

A study in rats demonstrated that the SV2B was less abundant in spinal cord tissue until 7 days post-contusion, then showed increased expression specifically at the injury epicenter at 35 days post-injury [Aimone et al. DOI:10.1016/j.expneurol.2004.05.042].