Basic Information

Symbol
SV2B
RNA class
mRNA
Alias
Synaptic Vesicle Glycoprotein 2B KIAA0735 HsT19680 SLC22B2 Solute Carrier Family 22 Member B2 Synaptic Vesicle Protein 2B Homolog
Location (GRCh38)
15:91099869-91302565
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001323032.3
Sequence length
12563.0 nt
GC content
0.4413

Transcripts

ID Sequence Length GC content
NM_014848.7 NCBI
GCCCGGAUCGCCCAGCUCCGCGUUAGCCGGAGCUGCACGCGGGGCUGCC… 12651 nt 0.4422
Showing 11 to 11 of 11 entries
Summary

This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons, and that this protein may be important for the integrity of the glomerular filtration barrier. This gene shows reduced expression in areas of synaptic loss in the hippocampus of human temporal lobe epilepsy patients. [provided by RefSeq, Sep 2016]

Forensic Context

A study in rats demonstrated that the SV2B was less abundant in spinal cord tissue until 7 days post-contusion, then showed increased expression specifically at the injury epicenter at 35 days post-injury [Aimone et al. DOI:10.1016/j.expneurol.2004.05.042].