Basic Information

Symbol
SYNE2
RNA class
mRNA
Alias
Spectrin Repeat Containing Nuclear Envelope Protein 2 Nesprin-2 NUA KIAA1011 SYNE-2 NUANCE Nesp2 Spectrin Repeat Containing, Nuclear Envelope 2 Nucleus And Actin Connecting Element Protein Nuclear Envelope Spectrin Repeat Protein 2 Synaptic Nuclear Envelope Protein 2 KASH Domain-Containing Protein 2 DKFZP434H2235 KASH2 Nucleus And Actin Connecting Element Nuclear Envelope Spectrin Repeat-2 Synaptic Nuclei Expressed Gene 2 Nesprin-2 Spectrin Repeats 3-54 Protein NUANCE Polytrophin Nesprin 2 Syne-2 EDMD5 TROPH
Location (GRCh38)
14:63761899-64226433
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_182914.3
Sequence length
21822.0 nt
GC content
0.4284

Transcripts

ID Sequence Length GC content
NM_015180.6 NCBI
AGCUGCGCCCAGAGCCUUCGGCCGGACCUGAAAAAGCGAGAGGGAGAGC… 21756 nt 0.4287
NM_182910.2 NCBI
CCGGCCUUGCCACUCAGUGUCCCUACCACUCGAGACCCUGGCUCCAAAA… 2586 nt 0.4919
NM_182913.4 NCBI
GCAGAAGCCUAUGAGUUGAUUAAUUCUAACAACUGGAUACUGUGGUUUA… 2670 nt 0.4985
NM_182914.3 NCBI
AGCUGCGCCCAGAGCCUUCGGCCGGACCUGAAAAAGCGAGAGGGAGAGC… 21822 nt 0.4284
Summary

The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Forensic Context

A study in humans identified the SYNE2 as an mRNA marker for age estimation, demonstrating its expression increases with age in dried blood stain RNA-Seq data [Dørum et al. DOI:10.1016/j.fsigen.2023.102976]. This marker was part of a lasso regression-selected gene list that achieved a mean absolute error of 4.46 years for age prediction in the primary dataset, establishing its utility in a forensic molecular assay for predicting a biological stain donor's chronological age.