Basic Information
MANE select
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| ACCGCGCGGGUGCAGCCACGAUGGAAGGGGGUGCGUACGGAGCGGGCAA… | 4383 nt | 0.6005 | |
| ACCGCGCGGGUGCAGCCACGAUGGAAGGGGGUGCGUACGGAGCGGGCAA… | 1287 nt | 0.5812 | |
| GCACUGCGGGACACGGCUCAGGACCAGCAGGCAUGCCUCCUUGGUCUCA… | 1318 nt | 0.5690 |
Summary
This gene encodes an integral membrane protein associated with presynaptic vesicles in neuronal cells. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it functions in synaptic plasticity without being required for synaptic transmission. The gene product belongs to the synaptogyrin gene family. Three alternatively spliced variants encoding three different isoforms have been identified. [provided by RefSeq, Jul 2008]
Forensic Context
A study in rats demonstrated that synaptogyrin (Syngr1) expression was part of a cluster of genes associated with secretory/synaptic processes whose expression was inversely correlated with injury severity following experimental spinal cord contusion, and this finding was validated by RT-PCR [De Biase et al. DOI:10.1152/physiolgenomics.00081.2005]. The expression of this synaptic protein was validated by RT-PCR, confirming the microarray findings regarding its alteration following injury.