Basic Information

Symbol
SYNJ1
RNA class
mRNA
Alias
Synaptojanin 1 Synaptic Inositol 1,4,5-Trisphosphate 5-Phosphatase 1 INPP5G PARK20 Inositol Polyphosphate-5-Phosphatase G Phosphoinositide 5-Phosphatase Synaptojanin-1 EC 3.1.3.36 Synaptojanin-1, Polyphosphoinositide Phosphatase Inositol 5'-Phosphatase (Synaptojanin 1) KIAA0910 EC 3.1.3 EIEE53 DEE53
Location (GRCh38)
21:32628757-32728040
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_203446.3
Sequence length
7068.0 nt
GC content
0.4184

Transcripts

ID Sequence Length GC content
NM_001160302.2 NCBI
GAGCUGCUGCGGCCAGACCCACGGGCAGCCGGGCGGGCGGACGCCUCCA… 7037 nt 0.4184
NM_001160306.2 NCBI
GAGCUGCUGCGGCCAGACCCACGGGCAGCCGGGCGGGCGGACGCCUCCA… 6920 nt 0.4175
NM_003895.4 NCBI
CUCUCCCGUCAGGCCCGUGGGGGCGGCGGGGUUGGUCCUGACGCCCAGC… 7425 nt 0.4334
NM_203446.3 NCBI
GGAAGUGACGCUCCCGGCGGCUGUGGCGGCGGCUGCGGGAGAAGGAGGA… 7068 nt 0.4184
Summary

This gene encodes a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4,5-bisphosphate. As such, expression of this enzyme may affect synaptic transmission and membrane trafficking. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Forensic Context

A study in rats demonstrated that the SYNJ1 was significantly altered in expression on day 7 following a 20% total body surface area burn injury, as identified through microarray analysis of liver tissue [Jayaraman et al. DOI:10.1016/j.jss.2007.05.025]. In a separate study of contusive spinal cord injury in rats, the SYNJ1 was identified as a synaptic vesicle protein with changes in expression found after injury [Aimone et al. DOI:10.1016/j.expneurol.2004.05.042].