Basic Information

Symbol
SYNJ2
RNA class
mRNA
Alias
Synaptojanin 2 Synaptic Inositol 1,4,5-Trisphosphate 5-Phosphatase 2 INPP5H Inositol Polyphosphate-5-Phosphatase H Phosphoinositide 5-Phosphatase Synaptojanin-2 EC 3.1.3.36 Inositol Phosphate 5'-Phosphatase 2 KIAA0348
Location (GRCh38)
6:157981863-158099176
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003898.4
Sequence length
7402.0 nt
GC content
0.4943

Transcripts

ID Sequence Length GC content
NM_001178088.2 NCBI
GUGUUUUCUUUUUGGAGUGGGUGGGAAGCCAGCUUGGCAAGCCGGGUGU… 7287 nt 0.4865
NM_001410947.1 NCBI
GAAACUCUGGCAAGUUGCGGGCGCGCGGGGAGCUGUCGCGGGCAGCGCG… 7552 nt 0.4936
NM_003898.4 NCBI
GAAACUCUGGCAAGUUGCGGGCGCGCGGGGAGCUGUCGCGGGCAGCGCG… 7402 nt 0.4943
Summary

The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Forensic Context

A study in human brain tissues demonstrated that ATAC-seq robustly identified trauma-induced chromatin accessibility changes, including marked alterations for the SYNJ2 in traumatic brain injury (TBI) samples, with no significant impact from 24-hour postmortem degradation [Xu et al. DOI:10.1016/J.Forsciint.2025.112789]. The method's efficacy was confirmed through high-quality sequencing metrics and stable detection of differential accessibility, supporting its forensic application for molecular diagnosis.