Basic Information

Symbol
SYT1
RNA class
mRNA
Alias
Synaptotagmin 1 P65 Synaptotagmin I SVP65 SYT Synaptotagmin-1 SytI BAGOS
Location (GRCh38)
12:78863650-79452009
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation Sudden death from CNS diseases
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005639.3
Sequence length
4705.0 nt
GC content
0.4111

Transcripts

ID Sequence Length GC content
NM_001135805.2 NCBI
GCUUCUCCCGCAUCUCGGCUCCACCGCACCCUUCGCGGGAAGUCCCCAG… 4835 nt 0.4130
NM_001135806.2 NCBI
AACAAGUUUGCCCAUUCAUCCUUGUGAUAGAUAUGCAUGCAAAACCAAA… 4371 nt 0.3887
NM_001291901.2 NCBI
AGUGUCUUUCCACCUCCUCCUGCAGCAGCGGCAGCGGCAGCAGCAGUUA… 4630 nt 0.4127
NM_001415938.1 NCBI
AGUGUCUUUCCACCUCCUCCUGCAGCAGCGGCAGCGGCAGCAGCAGUUA… 4639 nt 0.4132
NM_001415939.1 NCBI
AGUGUCUUUCCACCUCCUCCUGCAGCAGCGGCAGCGGCAGCAGCAGUUA… 4747 nt 0.4114
NM_001415940.1 NCBI
AGUGUCUUUCCACCUCCUCCUGCAGCAGCGGCAGCGGCAGCAGCAGUUA… 4794 nt 0.4113
NM_001415941.1 NCBI
AGUGUCUUUCCACCUCCUCCUGCAGCAGCGGCAGCGGCAGCAGCAGUUA… 4696 nt 0.4106
NM_001415942.1 NCBI
AACAAGUUUGCCCAUUCAUCCUUGUGAUAGAUAUGCAUGCAAAACCAAA… 4362 nt 0.3881
NM_001415943.1 NCBI
AGUGUCUUUCCACCUCCUCCUGCAGCAGCGGCAGCGGCAGCAGCAGUUA… 4785 nt 0.4109
NM_005639.3 NCBI
AGUGUCUUUCCACCUCCUCCUGCAGCAGCGGCAGCGGCAGCAGCAGUUA… 4705 nt 0.4111
Summary

This gene encodes a member of the synaptotagmin protein family. The synaptotagmins are integral membrane proteins of synaptic vesicles that serve as calcium sensors in the process of vesicular trafficking and exocytosis. The encoded protein participates in triggering neurotransmitter release at the synapse in response to calcium binding. Mutations in this gene are associated with Baker-Gordon syndrome. [provided by RefSeq, Jan 2023]

Forensic Context

A study in human post-mortem brain tissues demonstrated that the SYT1 mRNA and protein levels were significantly decreased in chronic traumatic encephalopathy (CTE) and Alzheimer's disease (AD) compared to normal subjects, with immunohistochemistry confirming markedly reduced immunoreactivity in neuronal cell bodies and dendrites [Cho et al. DOI:10.1038/s41598-020-65916-y].