Basic Information

Symbol
SYT4
RNA class
mRNA
Alias
Synaptotagmin 4 Synaptotagmin IV KIAA1342 HsT1192 Synaptotagmin-4 SytIV
Location (GRCh38)
18:43267892-43277535
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden death from CNS diseases Forensic psychiatry evaluation Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_020783.4
Sequence length
3936.0 nt
GC content
0.3788

Transcripts

ID Sequence Length GC content
NM_020783.4 NCBI
AGAAGAGCCAAAACAGGAACCGAGGUGGCAAAUCACUGUGCGAGGGCGA… 3936 nt 0.3788
Summary

Predicted to enable several functions, including calcium ion sensor activity; protein dimerization activity; and syntaxin binding activity. Involved in negative regulation of catecholamine secretion and positive regulation of dendrite extension. Predicted to be located in neuron projection terminus and secretory vesicle. Predicted to be active in several cellular components, including axon; glutamatergic synapse; and secretory vesicle. [provided by Alliance of Genome Resources, Apr 2025]

Forensic Context

A study in humans demonstrated that the SYT4 was down-regulated in chronic traumatic encephalopathy (CTE), CTE with Alzheimer's disease (CTE/AD), and Alzheimer's disease (AD) post-mortem brain tissues, associating it with synaptic transmission [Cho et al. DOI:10.1038/s41598-020-65916-y]. In a rat model of contusive spinal cord injury, the SYT4 was found to be downregulated at 3 hours post-injury but upregulated at 24 hours within the injury epicenter [Aimone et al. DOI:10.1016/j.expneurol.2004.05.042].