Basic Information

Symbol
SYT5
RNA class
mRNA
Alias
Synaptotagmin 5 Synaptotagmin V Synaptotagmin-5 SytV
Location (GRCh38)
19:55171196-55180314
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003180.3
Sequence length
3667.0 nt
GC content
0.5590

Transcripts

ID Sequence Length GC content
NM_001297774.2 NCBI
AGACCCUGCGGAGGGGCGAGGACGAGGCAGAAGUCAGCGGGAUGCCUGU… 3580 nt 0.5497
NM_003180.3 NCBI
ACACGGGCACACACGCGCGCACGGGAUCCUGCUCCGCUCCGCGGCUCCC… 3667 nt 0.5590
Summary

Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).[supplied by OMIM, Feb 2011]

Forensic Context

A study in human post-mortem brain tissue demonstrated that the SYT5 is an RNA marker associated with synaptic transmission and is down-regulated in chronic traumatic encephalopathy (CTE), CTE with Alzheimer's disease (CTE/AD), and Alzheimer's disease (AD) [Cho et al. DOI:10.1038/s41598-020-65916-y].