Basic Information

Symbol
SYT7
RNA class
mRNA
Alias
Synaptotagmin 7 IPCA-7 Synaptotagmin VII SYT-VII PCANAP7 Prostate Cancer-Associated Protein 7 Synaptotagmin-7 MGC150517 Prostate Cancer Associated Protein 7 SYTVII SytVII IPCA7
Location (GRCh38)
11:61513714-61581167
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden death from CNS diseases
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001365809.2
Sequence length
7230.0 nt
GC content
0.6003

Transcripts

ID Sequence Length GC content
NM_001252065.2 NCBI
GCACACGCGGCGCGCAGGCCGGAGGGAGGCGGCUCGGCGCUGUUCGGCG… 6606 nt 0.5982
NM_001300773.2 NCBI
GCACACGCGGCGCGCAGGCCGGAGGGAGGCGGCUCGGCGCUGUUCGGCG… 6513 nt 0.5905
NM_001365809.2 NCBI
GCACACGCGGCGCGCAGGCCGGAGGGAGGCGGCUCGGCGCUGUUCGGCG… 7230 nt 0.6003
NM_001370211.1 NCBI
GCACACGCGGCGCGCAGGCCGGAGGGAGGCGGCUCGGCGCUGUUCGGCG… 2352 nt 0.5867
NM_001411007.1 NCBI
GCACACGCGGCGCGCAGGCCGGAGGGAGGCGGCUCGGCGCUGUUCGGCG… 6738 nt 0.5959
NM_004200.4 NCBI
GCACACGCGGCGCGCAGGCCGGAGGGAGGCGGCUCGGCGCUGUUCGGCG… 6381 nt 0.5929
Summary

This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Forensic Context

A study in human post-mortem brain tissue demonstrated that the SYT7 was down-regulated in chronic traumatic encephalopathy (CTE), CTE with Alzheimer's disease (CTE/AD), and Alzheimer's disease (AD) and was identified as a top 10 hub gene in a co-expression network module associated with synaptic transmission and memory function [Cho et al. DOI:10.1038/s41598-020-65916-y].