Basic Information

Symbol
TAB2
RNA class
mRNA
Alias
TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2 MAP3K7IP2 KIAA0733 Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 2 TGF-Beta-Activated Kinase 1 And MAP3K7-Binding Protein 2 TAK1-Binding Protein 2 TAB-2 Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 2 TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 2 TGF-Beta-Activated Kinase 1-Binding Protein 2 TAK1 Binding Protein 2 CHTD2
Location (GRCh38)
6:149218641-149411613
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001292034.3
Sequence length
4363.0 nt
GC content
0.4275

Transcripts

ID Sequence Length GC content
NM_001292034.3 NCBI
GUCGUUUUUGAUCUGCUGCAGCCGCCGGCGGGGCGACCCAGCCCGACCC… 4363 nt 0.4275
NM_001292035.3 NCBI
CUUUCUGGAGUCUGAAAUGUUAAGUAUGGAGGCAAAAGCUGAAGCUGGA… 4181 nt 0.4033
NM_001369506.1 NCBI
GUCGUUUUUGAUCUGCUGCAGCCGCCGGCGGGGCGACCCAGCCCGACCC… 4512 nt 0.4275
NM_015093.6 NCBI
AUCGAGCGCCUAGGAGAGCCCCGGGUGGGGGAGGGCGCAAGGGGCUCGG… 4391 nt 0.4113
Summary

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Forensic Context

A study in Sprague-Dawley rats demonstrated that the mRNA expression level of the TAB2 was used as one of four original biomarkers in an optimized "up, no change, or down" model for wound age estimation in contused skeletal muscle [Dang et al. DOI:10.1007/s00414-020-02411-z].