Basic Information

Symbol
TAC1
RNA class
mRNA
Alias
Tachykinin Precursor 1 NKNA TAC2 NPK Tachykinin, Precursor 1 (Substance K, Substance P, Neurokinin 1, Neurokinin 2, Neuromedin L, Neurokinin Alpha, Neuropeptide K, Neuropeptide Gamma) Neuropeptide Gamma Neurokinin Alpha Preprotachykinin Protachykinin-1 Neuropeptide K Protachykinin Neurokinin 1 Neurokinin 2 Neuromedin L Substance K Substance P PPT Neurokinin A Tachykinin 2 Hs.2563 NK2 NKA
Location (GRCh38)
7:97732053-97740472
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003182.3
Sequence length
1061.0 nt
GC content
0.3930

Transcripts

ID Sequence Length GC content
NM_003182.3 NCBI
AGAGCGCGCUCGGACCUCCUUCCCGGCGGCAGCUACCGAGAGUGCGGAG… 1061 nt 0.3930
NM_013996.3 NCBI
AGAGCGCGCUCGGACCUCCUUCCCGGCGGCAGCUACCGAGAGUGCGGAG… 1007 nt 0.3952
NM_013997.3 NCBI
AGAGCGCGCUCGGACCUCCUUCCCGGCGGCAGCUACCGAGAGUGCGGAG… 1016 nt 0.3937
NM_013998.3 NCBI
AGAGCGCGCUCGGACCUCCUUCCCGGCGGCAGCUACCGAGAGUGCGGAG… 962 nt 0.3960
Summary

This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

Forensic Context

A study in rats demonstrated that a single administration of MDMA significantly increased the mRNA expression of the TAC1 in specific striatal subregions and the nucleus accumbens core 3 hours post-injection, as measured by in situ hybridization [Adams et al. DOI:10.1016/J.Molbrainres.2004.10.005].