Basic Information

Symbol
TACR1
RNA class
mRNA
Alias
Tachykinin Receptor 1 NK1R SPR Substance-P Receptor TAC1R NKIR Neurokinin Receptor 1 NK-1 Receptor NK-1R Tachykinin Receptor 1 (Substance P Receptor; Neurokinin-1 Receptor)
Location (GRCh38)
2:75046463-75199520
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001058.4
Sequence length
4779.0 nt
GC content
0.4863

Transcripts

ID Sequence Length GC content
NM_001058.4 NCBI
GAGCUGAGCAACCCGAACCGAGAGGUGCCCGCGAAACUGCAGGCGGCGG… 4779 nt 0.4863
NM_015727.3 NCBI
GAGCUGAGCAACCCGAACCGAGAGGUGCCCGCGAAACUGCAGGCGGCGG… 1733 nt 0.5378
Summary

This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]

Forensic Context

A study in female Wistar rats demonstrated that the TACR1 mRNA was not detectable in adhesiogenic peritoneal tissue from ischemic lesions, while it was actively expressed in contralateral non-adhesiogenic peritoneum at post-operative day 3, a difference that was statistically highly significant [Kraemer et al. DOI:10.1007/s00404-011-2041-4].