Basic Information

Symbol
TAF15
RNA class
mRNA
Alias
TATA-Box Binding Protein Associated Factor 15 RBP56 TAF2N Npl3 TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, N, 68kD (RNA-Binding Protein 56) TAF15 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 68kDa TATA-Binding Protein-Associated Factor 2N HTAFII68 TAFII68 TATA Box-Binding Protein-Associated Factor 2N (RNA-Binding Protein 56) 68 KDa TATA-Binding Protein-Associated Factor TBP-Associated Factor 15 RNA-Binding Protein 56 RBP56/CSMF Fusion TAF(II)68
Location (GRCh38)
17:35809481-35864615
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_139215.3
Sequence length
2162.0 nt
GC content
0.5069

Transcripts

ID Sequence Length GC content
NM_003487.4 NCBI
AGUACAGCUCCGGCCGCCGCGCCGCCUGGCUUUCGUAUUCGUUGUUCUC… 2153 nt 0.5067
NM_139215.3 NCBI
AGUACAGCUCCGGCCGCCGCGCCGCCUGGCUUUCGUAUUCGUUGUUCUC… 2162 nt 0.5069
Summary

This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Forensic Context

A study in human postmortem brain tissue identified TAF15 as a differentially expressed protein in the dorsolateral prefrontal cortex of subjects with opioid use disorder (OUD) compared to non-psychiatric controls [Mendez et al. DOI:10.1038/s41380-021-01259-y].