Basic Information

Symbol
TAF1C
RNA class
mRNA
Alias
TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit C TAFI110 MGC:39976 TAFI95 SL1 TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, C, 110kDa TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, C, 110kD TATA Box-Binding Protein-Associated Factor RNA Polymerase I Subunit C RNA Polymerase I-Specific TBP-Associated Factor 110 KDa Transcription Initiation Factor SL1/TIF-IB Subunit C TATA Box-Binding Protein-Associated Factor 1C TBP-Associated Factor 1C TATA-Box Binding Protein Associated Factor, RNA Polymerase I, C Transcription Factor SL1 SL1, 110kD Subunit
Location (GRCh38)
16:84177846-84187070
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001243156.2
Sequence length
3847.0 nt
GC content
0.6179

Transcripts

ID Sequence Length GC content
NM_001243156.2 NCBI
GGUCCAAACCGGAAGACCGUGGGUAGCUGCGGCGGGGCUGACCCGUCCC… 3847 nt 0.6179
NM_001243157.2 NCBI
GGUCCAAACCGGAAGACCGUGGGUAGCUGCGGCGGGGCUGACCCGUCCC… 3481 nt 0.6176
NM_001243158.2 NCBI
GGUCCAAACCGGAAGACCGUGGGUAGCUGCGGCGGGGCUGACCCGUCCC… 3342 nt 0.6173
NM_001243159.2 NCBI
GGUCCAAACCGGAAGACCGUGGGUAGCUGCGGCGGGGCUGACCCGUCCC… 3814 nt 0.6190
NM_001243160.2 NCBI
GGUCCAAACCGGAAGACCGUGGGUAGCUGCGGCGGGGCUGACCCGUCCC… 3659 nt 0.6166
NM_005679.4 NCBI
GGUCCAAACCGGAAGACCGUGGGUAGCUGCGGCGGGGCUGACCCGUCCC… 3925 nt 0.6168
NM_139353.3 NCBI
GGUCCAAACCGGAAGACCGUGGGUAGCUGCGGCGGGGCUGACCCGUCCC… 3683 nt 0.6185
Summary

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]

Forensic Context

A study in humans demonstrated that the TAF1C gene was downregulated as part of the inhibited epigenetic regulation of gene expression pathway specifically in the lungs of patients who succumbed to septic shock [Pinheiro da Silva et al. DOI:10.1111/jcmm.17938].