Basic Information

Symbol
TAOK2
RNA class
mRNA
Alias
TAO Kinase 2 MAP3K17 HKFC-C PSK-1 PSK1 PSK Thousand And One Amino Acid Protein Kinase 2 Prostate-Derived Sterile 20-Like Kinase 1 Serine/Threonine-Protein Kinase TAO2 Kinase From Chicken Homolog C PSK1-BETA KIAA0881 Tao2beta TAO1 TAO2 Prostate-Derived STE20-Like Kinase 1 EC 2.7.11.1 Prostate Derived STE20-Like Kinase PSK EC 2.7.11
Location (GRCh38)
16:29973868-29992261
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_016151.4
Sequence length
4937.0 nt
GC content
0.6192

Transcripts

ID Sequence Length GC content
NM_001252043.2 NCBI
CUCCAUCUUGGAAUUGGGAGGAAGAGGGAGAGGGAGACCGGGACGAGAC… 4598 nt 0.6205
NM_004783.4 NCBI
CUCCAUCUUGGAAUUGGGAGGAAGAGGGAGAGGGAGACCGGGACGAGAC… 4659 nt 0.6175
NM_016151.4 NCBI
CUCCAUCUUGGAAUUGGGAGGAAGAGGGAGAGGGAGACCGGGACGAGAC… 4937 nt 0.6192
Summary

Enables mitogen-activated protein kinase kinase binding activity; neuropilin binding activity; and protein serine/threonine kinase activity. Involved in several processes, including focal adhesion assembly; intracellular signal transduction; and positive regulation of MAPK cascade. Located in cytoplasmic vesicle; cytosol; and nuclear lumen. Part of receptor complex. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans demonstrated that the TAOK2 mRNA showed suggestively higher expression in platelets from patients with ST-segment elevation myocardial infarction (STEMI) compared to those with non-STEMI (NSTEMI) [Eicher et al. DOI:10.3109/09537104.2015.1083543]. A study in humans identified numerous differentially expressed genes in blood from myocardial infarction patients, including the TAOK2 which was mentioned in the introduction as a potential biomarker for MI [Zhao et al. DOI:10.3892/etm.2017.5580].