Basic Information
Symbol
TAOK3
RNA class
mRNA
Alias
TAO Kinase 3
MAP3K18
JIK
DPK
Cutaneous T-Cell Lymphoma-Associated Antigen HD-CL-09
Dendritic Cell-Derived Protein Kinase
Thousand And One Amino Acid Protein 3
Serine/Threonine-Protein Kinase TAO3
CTCL-Associated Antigen HD-CL-09
Kinase From Chicken Homolog A
Jun Kinase-Inhibitory Kinase
JNK/SAPK-Inhibitory Kinase
EC 2.7.11.1
HKFC-A
STE20-Like Kinase
EC 2.7.11
KDS
Location (GRCh38)
12:118149801-118372920
Forensic tag(s)
Other applications
MANE select
Transcript ID
NM_016281.4
Sequence length
4346.0 nt
GC content
0.4429
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| AGAACUGUGUACGAUCAUGACUGGAAAGCAGGAUCCCUCAGUGACUGCC… | 2041 nt | 0.4454 | |
| AGGAGCCGCACCUCGGACAGCAGCAGCGGCGGCGGCCGCGGGAGGGUCC… | 4346 nt | 0.4429 |
Showing 11 to 12 of 12 entries
Summary
The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]
Forensic Context
A longitudinal mRNA expression analysis in post-mortem human blood samples identified two groups of up- and down-regulated genes, with pathway analysis indicating active processes promoting cell survival and DNA damage repair shortly after death [Antiga et al. DOI:10.1038/s41598-021-96095-z].