Basic Information

Symbol
TAP1
RNA class
mRNA
Alias
Transporter 1, ATP Binding Cassette Subfamily B Member RING4 PSF1 D6S114E ABCB2 Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP) Peptide Transporter Involved In Antigen Processing 1 ATP-Binding Cassette Sub-Family B Member 2 Really Interesting New Gene 4 Protein Antigen Peptide Transporter 1 Peptide Transporter PSF1 Peptide Transporter TAP1 Peptide Supply Factor 1 PSF-1 APT1 Transporter, ATP-Binding Cassette, Major Histocompatibility Complex, 1 ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 2 Transporter 1 ATP-Binding Cassette Sub-Family B Transporter Associated With Antigen Processing ABC Transporter, MHC 1 EC 7.4.2.14 TAP1*0102N MHC1D1 ABC17 TAP1N Y3
Location (GRCh38)
6:32845206-32854018
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000593.6
Sequence length
2685.0 nt
GC content
0.5739

Transcripts

ID Sequence Length GC content
NM_000593.6 NCBI
GCUUCAGGCCCCACCGGGGCGCGGAGAGUCCCAGGCCCGGCCGGGACCG… 2685 nt 0.5739
NM_001292022.2 NCBI
CUCAUCUCUAACAGGAGGCUUUUCUACUUCAUGAUCUCCAGCCUUCCUA… 2186 nt 0.5306
Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Forensic Context

No relevant information is available at the moment.