Basic Information

Symbol
TAPBP
RNA class
mRNA
Alias
TAP Binding Protein NGS17 TAPA TPSN TPN Tapasin TAP Binding Protein (Tapasin) TAP-Associated Protein NGS-17 TAP-Binding Protein MHC1D3
Location (GRCh38)
6:33299694-33314284
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003190.5
Sequence length
3450.0 nt
GC content
0.5707

Transcripts

ID Sequence Length GC content
NM_001410875.1 NCBI
GAAGAGGAGGCUUCAUGGCUGAGGAGGUCGCAGCGCCAUGAAGUCCCUG… 3415 nt 0.5716
NM_003190.5 NCBI
GAAGAGGAGGCUUCAUGGCUGAGGAGGUCGCAGCGCCAUGAAGUCCCUG… 3450 nt 0.5707
NM_172208.3 NCBI
GAAGAGGAGGCUUCAUGGCUGAGGAGGUCGCAGCGCCAUGAAGUCCCUG… 1721 nt 0.5892
NM_172209.3 NCBI
GAAGAGGAGGCUUCAUGGCUGAGGAGGUCGCAGCGCCAUGAAGUCCCUG… 3189 nt 0.5613
Summary

This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Forensic Context

A single-cell transcriptomic analysis in a rat model of radiation-induced lung injury identified the TAPBP as an orthologous rat gene associated with inflammatory processes [Shi et al. DOI:10.17305/bb.2024.10357].