Basic Information

Symbol
TARBP2
RNA class
mRNA
Alias
TARBP2 Subunit Of RISC Loading Complex Trbp TARBP2, RISC Loading Complex RNA Binding Subunit Trans-Activation Responsive RNA-Binding Protein RISC-Loading Complex Subunit TARBP2 TAR (HIV-1) RNA Binding Protein 2 TAR (HIV) RNA-Binding Protein 2 TAR RNA Binding Protein 2 Trans-Activation-Responsive RNA-Binding Protein TAR (HIV) RNA-Binding Protein TRBP1 TAR RNA-Binding Protein 2 TRBP1 TRBP2 LOQS TRBP
Location (GRCh38)
12:53500921-53506431
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_134323.2
Sequence length
1510.0 nt
GC content
0.6007

Transcripts

ID Sequence Length GC content
NM_004178.5 NCBI
CUCUCCAGCUGCGACACAGAUGGCGCGCGGGCUCUUGGGUUCUGUAGUU… 1405 nt 0.5851
NM_134323.2 NCBI
AGCGUGCCCCGCGGCGGGCCCUACCGGCCGCGACUCCGGGCUUGGCCCC… 1510 nt 0.6007
NM_134324.3 NCBI
AGUGGUUCCCGGCGUGCACCGGGGCAGUGGCUGCUGCCUCCAGCUCUAA… 1454 nt 0.5839
Summary

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008]

Forensic Context

A review of microRNA (miRNA) biogenesis, function, and regulation across diverse species including human, mouse, Drosophila melanogaster, and Arabidopsis thaliana synthesizes that the transactivation responsive RNA-binding protein (TRBP) acts as a cofactor for human Dicer, enhancing substrate capture and promoting the catalytic state for pre-miRNA processing [Shang et al. DOI:10.1038/s41576-023-00611-y].