Basic Information

Symbol
TAT
RNA class
mRNA
Alias
Tyrosine Aminotransferase L-Tyrosine:2-Oxoglutarate Aminotransferase EC 2.6.1.5 Testis Tissue Sperm-Binding Protein Li 34a Tyrosine Aminotransferase, Cytosolic
Location (GRCh38)
16:71565660-71577095
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000353.3
Sequence length
3945.0 nt
GC content
0.4416

Transcripts

ID Sequence Length GC content
NM_000353.3 NCBI
AUUGCCCCUGUAACCUGUCAAAGAAGAGCUAAGGGAGCUUUCGGGGUUG… 3945 nt 0.4416
Summary

This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible cognitive disability. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq, Jul 2008]

Forensic Context

A study in *Lophophora williamsii* demonstrated that the expression of the TAT (specifically unigene NFSLW_ISO0055341, annotated as tyrosine aminotransferase/nicotianamine aminotransferase) was more highly expressed in specimens without mescaline, while another unigene (NFSLW_ISO0024105, annotated as probable aminotransferase TAT2/tyrosine aminotransferase) showed higher expression in specimens containing mescaline, with both associated with isoquinoline alkaloid biosynthesis pathways [Hwang et al. DOI:10.1111/1556-4029.15679].