Basic Information

Symbol
TAX1BP1
RNA class
mRNA
Alias
Tax1 Binding Protein 1 CALCOCO3 TXBP151 Tax1 (Human T-Cell Leukemia Virus Type I) Binding Protein 1 Tax1-Binding Protein 1 TRAF6-Binding Protein T6BP
Location (GRCh38)
7:27739331-27844564
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006024.7
Sequence length
3423.0 nt
GC content
0.3780

Transcripts

ID Sequence Length GC content
NM_001079864.3 NCBI
GGUCUUUGGGGGUAGGCGGUAGUGGCGGAAGAGGUUCGGCGGCUGAUGG… 3297 nt 0.3773
NM_001206901.1 NCBI
ACGGCAACAGAAGACUAUGAUGAAUUCGAAUGGGACACAUUUGCUUCUG… 3383 nt 0.3686
NM_001206902.2 NCBI
GGUCUUUGGGGGUAGGCGGUAGUGGCGGAAGAGGUUCGGCGGCUGAUGG… 3109 nt 0.3750
NM_001362794.2 NCBI
GGUCUUUGGGGGUAGGCGGUAGUGGCGGAAGAGGUUCGGCGGCUGAUGG… 3393 nt 0.3778
NM_001362795.2 NCBI
GGUCUUUGGGGGUAGGCGGUAGUGGCGGAAGAGGUUCGGCGGCUGAUGG… 3102 nt 0.3714
NM_006024.7 NCBI
GGUCUUUGGGGGUAGGCGGUAGUGGCGGAAGAGGUUCGGCGGCUGAUGG… 3423 nt 0.3780
Summary

This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates the TAX1BP1 in microglia, where it is associated with the mitophagy pathway [Oladapo et al. DOI:10.3390/Ijms26020649].