Basic Information

Symbol
TBC1D10C
RNA class
mRNA
Alias
TBC1 Domain Family Member 10C Carabin EPI64C FLJ00332 TBC1 Domain Family, Member 10C
Location (GRCh38)
11:67398454-67410092
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001369496.1
Sequence length
1796.0 nt
GC content
0.6581

Transcripts

ID Sequence Length GC content
NM_001256508.1 NCBI
GAGGAGGAGGAGGAAGUGAGAGGAGGAGGCCCCGGGCACCAUGGCCCAG… 1541 nt 0.6457
NM_001369492.1 NCBI
GAGAUACCCUGAAACCUCCCCCCUCUGACCCCGCAGCCAGGCCCCAGGC… 1491 nt 0.6533
NM_001369494.1 NCBI
GAGAGGAGGAGGCCCCGGGCACCAUGGCCCAGGCCCUGGGGGAGGACCU… 1695 nt 0.6578
NM_001369495.1 NCBI
GAGAUACCCUGAAACCUCCCCCCUCUGACCCCGCAGCCAGGCCCCAGGC… 1792 nt 0.6579
NM_001369496.1 NCBI
GAGAUACCCUGAAACCUCCCCCCUCUGACCCCGCAGCCAGGCCCCAGGC… 1796 nt 0.6581
NM_001369497.1 NCBI
GAGAGGAGGAGGCCCCGGGCACCAUGGCCCAGGCCCUGGGGGAGGACCU… 1699 nt 0.6580
NM_001369498.1 NCBI
GAGAUACCCUGAAACCUCCCCCCUCUGACCCCGCAGCCAGGCCCCAGGC… 1820 nt 0.6593
NM_198517.4 NCBI
GAGAGGAGGAGGUGAGGUGCUGCGGGAGGCCCCGGGCACCAUGGCCCAG… 1716 nt 0.6585
Summary

The protein encoded by this gene has an N-terminal Rab-GTPase domain and a binding site at the C-terminus for calcineurin, and is an inhibitor of both the Ras signaling pathway and calcineurin, a phosphatase regulated by calcium and calmodulin. Genes encoding similar proteins are located on chromosomes 16 and 22. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

Forensic Context

A study in Wistar-albino rats demonstrated that the TBC1D10C gene, identified as differentially expressed in response to mild traumatic brain injury, was down-regulated at 12 hours post-trauma and subsequently up-regulated at 48 hours [Colak et al. DOI:10.1016/j.injury.2012.01.021].