Basic Information

Symbol
TBC1D15
RNA class
mRNA
Alias
TBC1 Domain Family Member 15 GTPase-Activating Protein RAB7 DKFZp761D0223 GAP For RAB7 FLJ12085 Tre-2-Budding Uninhibited By Benzimidazole-Cell Division Cycle 16 Domain, Domain Family Member 15 Tre2/Bub2/Cdc16 Domain Family Member 15 TBC1 Domain Family, Member 15 RAB7-GAP Rab7-GAP
Location (GRCh38)
12:71839707-71927248
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001146213.3
Sequence length
3157.0 nt
GC content
0.3491

Transcripts

ID Sequence Length GC content
NM_001146213.3 NCBI
AUUACCAGGCACGCGCAGGAAACAUGGCGGCGGCGGGUGUUGUGAGCGG… 3157 nt 0.3491
NM_001146214.3 NCBI
AUUACCAGGCACGCGCAGGAAACAUGGCGGCGGCGGGUGUUGUGAGCGG… 3249 nt 0.3496
NM_001385848.1 NCBI
AUUACCAGGCACGCGCAGGAAACAUGGCGGCGGCGGGUGUUGUGAGCGG… 3151 nt 0.3488
NM_001385849.1 NCBI
AUUACCAGGCACGCGCAGGAAACAUGGCGGCGGCGGGUGUUGUGAGCGG… 3124 nt 0.3492
NM_001385850.1 NCBI
AUUACCAGGCACGCGCAGGAAACAUGGCGGCGGCGGGUGUUGUGAGCGG… 3097 nt 0.3494
NM_001385851.1 NCBI
AUUACCAGGCACGCGCAGGAAACAUGGCGGCGGCGGGUGUUGUGAGCGG… 3091 nt 0.3497
NM_001385852.1 NCBI
AUUACCAGGCACGCGCAGGAAACAUGGCGGCGGCGGGUGUUGUGAGCGG… 3082 nt 0.3475
NM_001385853.1 NCBI
AUUACCAGGCACGCGCAGGAAACAUGGCGGCGGCGGGUGUUGUGAGCGG… 3040 nt 0.3503
NM_001385854.1 NCBI
AUUACCAGGCACGCGCAGGAAACAUGGCGGCGGCGGGUGUUGUGAGCGG… 2983 nt 0.3480
NM_022771.6 NCBI
AUUACCAGGCACGCGCAGGAAACAUGGCGGCGGCGGGUGUUGUGAGCGG… 3208 nt 0.3516
Summary

This gene encodes a member of the Ras-like proteins in brain-GTPase activating protein superfamily that share a conserved Tre-2/Bub2/Cdc16 domain. The encoded protein interacts with Ras-like protein in brain 5A and may function as a regulator of intracellular trafficking. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Forensic Context

A study in mice and humans demonstrated that the TBC1D15 is an oncofetal protein that mediates p53 degradation by dissociating NUMB from p53, promoting the self-renewal of tumor-initiating stem-like cells in hepatocellular carcinoma [Machida et al. DOI:10.1016/J.Cbi.2020.109055].