Basic Information

Symbol
TBC1D5
RNA class
mRNA
Alias
TBC1 Domain Family Member 5 KIAA0210 TBC1 Domain Family, Member 5
Location (GRCh38)
3:17157162-18444817
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001349074.2
Sequence length
6500.0 nt
GC content
0.4545

Transcripts

ID Sequence Length GC content
NM_001134381.2 NCBI
GUAUUGAGUCACCAUAAGUGGACAAGGAAGGAGCUUCUAACAGACCUCA… 6513 nt 0.4486
NM_001349073.2 NCBI
GCCACCCCCUCCCGCCCUGUUCUCUUUCAGGUCGGGCCGGGCCCGGCCG… 6435 nt 0.4559
NM_001349074.2 NCBI
GCCACCCCCUCCCGCCCUGUUCUCUUUCAGGUCGGGCCGGGCCCGGCCG… 6500 nt 0.4545
NM_001349075.2 NCBI
GCCACCCCCUCCCGCCCUGUUCUCUUUCAGGUCGGGCCGGGCCCGGCCG… 6529 nt 0.4586
NM_001349076.2 NCBI
GCCACCCCCUCCCGCCCUGUUCUCUUUCAGGUCGGGCCGGGCCCGGCCG… 6530 nt 0.4524
NM_001349077.2 NCBI
GCCACCCCCUCCCGCCCUGUUCUCUUUCAGGUCGGGCCGGGCCCGGCCG… 6493 nt 0.4568
NM_001349078.2 NCBI
GCCACCCCCUCCCGCCCUGUUCUCUUUCAGGUCGGGCCGGGCCCGGCCG… 6434 nt 0.4540
NM_001349079.2 NCBI
GCCACCCCCUCCCGCCCUGUUCUCUUUCAGGUCGGGCCGGGCCCGGCCG… 6639 nt 0.4522
NM_001349080.2 NCBI
GCCACCCCCUCCCGCCCUGUUCUCUUUCAGGUCGGGCCGGGCCCGGCCG… 6369 nt 0.4555
NM_001349081.2 NCBI
GCCACCCCCUCCCGCCCUGUUCUCUUUCAGGUCGGGCCGGGCCCGGCCG… 6487 nt 0.4568
Showing 1 to 10 of 21 entries
Summary

Enables AP-2 adaptor complex binding activity and retromer complex binding activity. Involved in several processes, including macroautophagy; positive regulation of receptor internalization; and retrograde transport, endosome to Golgi. Located in several cellular components, including Atg1/ULK1 kinase complex; autophagosome; and cytoplasmic vesicle membrane. Part of retromer complex. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in Wistar-albino rats demonstrated that the TBC1D5 gene, identified as part of the response to brain injury, was down-regulated at 12 hours post-mild traumatic brain injury and subsequently up-regulated at 48 hours [Colak et al. DOI:10.1016/j.injury.2012.01.021].