Basic Information

Symbol
TBX4
RNA class
mRNA
Alias
T-Box Transcription Factor 4 T-Box Transcription Factor TBX4 T-Box Protein 4 T-Box 4 PAPPAS ICPPS SPS
Location (GRCh38)
17:61451906-61485110
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001321120.2
Sequence length
3394.0 nt
GC content
0.5268

Transcripts

ID Sequence Length GC content
NM_001321120.2 NCBI
AGAGCCGGGAUGUGUCCAGCCCCGAGGGCACGGCAGGCAGCUGGACCCU… 3394 nt 0.5268
NM_018488.3 NCBI
GAGAUGCUGCAGGAUAAGGGCCUGUCCGAGAGCGAGGAGGCCUUCCGGG… 3251 nt 0.5134
Summary

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly this gene, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for this gene in regulating limb development and specification of limb identity. [provided by RefSeq, Jul 2008]

Forensic Context

A study in rats demonstrated that the TBX4 (T-box transcription factor 4) was significantly upregulated in fetal cardiac fibroblasts compared to neonatal cardiac fibroblasts, as identified through RNA sequencing analysis [Perreault et al. DOI:10.1152/physiolgenomics.00074.2021].