Basic Information

Symbol
TBXA2R
RNA class
mRNA
Alias
Thromboxane A2 Receptor Prostanoid TP Receptor TXA2-R BDPLT13
Location (GRCh38)
19:3594506-3606895
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001060.6
Sequence length
2642.0 nt
GC content
0.6347

Transcripts

ID Sequence Length GC content
NM_001060.6 NCBI
AGAGACUGGACGGAGAGAGCGAGCCGCGGGCUGCCAGCGGCCCCCACCC… 2642 nt 0.6347
NM_201636.3 NCBI
AGAGACUGGACGGAGAGAGCGAGCCGCGGGCUGCCAGCGGCCCCCACCC… 1982 nt 0.6519
Summary

This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Forensic Context

A study in humans demonstrated that the TBXA2R is highly expressed in cavernosal trabecular smooth muscle cells (CCSMC) and is involved in smooth muscle contraction via thromboxane signalling, with its expression upregulated in patients with diabetes mellitus erectile dysfunction [Zhao et al. DOI:10.1038/s41467-022-31950-9]. In a separate human study, exosomal mRNA for the TBXA2R was found to be upregulated in the plasma of patients with heat stroke, where it was associated with platelet activation pathways [Li et al. DOI:10.3389/fimmu.2021.624753].