Basic Information

Symbol
TBXAS1
RNA class
mRNA
Alias
Thromboxane A Synthase 1 CYP5A1 CYP5 TXAS TXS THAS TS Cytochrome P450, Family 5, Subfamily A, Polypeptide 1 Hydroperoxy Icosatetraenoate Dehydratase Thromboxane A Synthase 1 (Platelet) Thromboxane-A Synthase Cytochrome P450 5A1 TXA Synthase EC 5.3.99.5 Thromboxane A Synthase 1 (Platelet, Cytochrome P450, Subfamily V) Platelet, Cytochrome P450, Subfamily V EC 4.2.1.152 BDPLT14 GHOSAL
Location (GRCh38)
7:139777051-140020325
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Time since deposition estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001061.7
Sequence length
1923.0 nt
GC content
0.5273

Transcripts

ID Sequence Length GC content
NM_001061.7 NCBI
ACUCCAUGUGAUGUUUGCUUGGUUGCCUGUUCCCUUUUCUACCUGCAGA… 1923 nt 0.5273
NM_001130966.5 NCBI
GGGUGAGAGGGCCGGCCUGGACCCGGCGGGCGCACGGCUCCGAGCCCAG… 2343 nt 0.5433
NM_001166253.4 NCBI
ACUCCAUGUGAUGUUUGCUUGGUUGCCUGUUCCCUUUUCUACCUGCAGA… 2061 nt 0.5235
NM_001166254.4 NCBI
GGGUGAGAGGGCCGGCCUGGACCCGGCGGGCGCACGGCUCCGAGCCCAG… 2090 nt 0.5431
NM_001314028.4 NCBI
ACUCCAUGUGAUGUUUGCUUGGUUGCCUGUUCCCUUUUCUACCUGCAGA… 1952 nt 0.5241
NM_001366537.3 NCBI
ACUCCAUGUGAUGUUUGCUUGGUUGCCUGUUCCCUUUUCUACCUGCAGA… 1826 nt 0.5340
NM_001366538.2 NCBI
ACUCCAUGUGAUGUUUGCUUGGUUGCCUGUUCCCUUUUCUACCUGCAGA… 1425 nt 0.5025
NM_030984.6 NCBI
ACUCCAUGUGAUGUUUGCUUGGUUGCCUGUUCCCUUUUCUACCUGCAGA… 1760 nt 0.5142
Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Forensic Context

A study in humans demonstrated that the TBXAS1 was identified as a top five upregulated long noncoding RNA in traumatic brain injury tissues, with its expression verified by qRT-PCR [Zhang et al. DOI:10.097/WNR.0000000000001756]. In a separate forensic investigation in humans, the TBXAS1 was evaluated as an mRNA candidate for predicting the time-of-day of bloodstain deposition but was removed from the final predictive model due to high correlation with other markers [Gosch et al. DOI:10.1101/2025.02.03.636230].