Basic Information

Symbol
TCEAL1
RNA class
mRNA
Alias
Transcription Elongation Factor A Like 1 SIIR Pp21 WEX9 P21 Transcription Elongation Factor S-II Protein-Like 1 Transcription Elongation Factor A Protein-Like 1 Transcription Elongation Factor A (SII)-Like 1 Nuclear Phosphoprotein P21/SIIR TCEA-Like Protein 1 NEDGFAX HIJRS
Location (GRCh38)
X:103628701-103630958
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004780.3
Sequence length
1200.0 nt
GC content
0.4242

Transcripts

ID Sequence Length GC content
NM_001006639.2 NCBI
CCUGUCCACCAUCUCCCUAUUACCCUUUGGUCGAGAGGGAAAGCAGAAG… 1188 nt 0.4217
NM_001006640.2 NCBI
ACAGAGGAAGAGGCAAUACUACCCGAGACUAGAUGCGGACCGUCUCUGG… 1215 nt 0.4230
NM_004780.3 NCBI
CCUGUCCACCAUCUCCCUAUUACCCUUUGGUCGAGAGGGAAAGCAGAAG… 1200 nt 0.4242
Summary

This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans identified the TCEAL1 as a radiation-inducible mRNA biomarker found increased in whole blood extract after total body radiation of cancer patients [Chen et al. DOI:10.1016/j.ijrobp.2005.10.014].